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INVESTIGATING MECHANISMS OF STEM CELL REGULATION IN EPITHELIAL DEVELOPMENT AND DISEASE

RESEARCH INTERESTS

  • Tumor Microenvironment

    HOW DO DIVERSE CELL TYPES IMPACT EPITHELIAL STEM CELL BEHAVIOR DURING CANCER DEVELOPMENT?

    HOW IS CELL HETEROGENEITY ALTERED DURING TUMORIGENESIS?

    WHAT CELL-CELL INTERACTIONS DRIVE CANCER?

  • Inflammasome Biology

    WHAT STIMULI PROMOTE INFLAMMASOME ACTIVATION IN DISTINCT CELL TYPES?

    IS INFLAMMASOME ACTIVATION CELL AUTONOMOUS?

    WHAT IS THE ROLE OF INFLAMMASOME SIGNALING IN EPITHELIAL DISEASE?

  • Stem Cell Fate

    WHAT INTRINSIC/EXTRINSIC SIGNALS DICTATE STEM CELL FATE DECISIONS?

    WHAT FACTORS CAUSE EPITHELIAL STEM CELL FATE MIS-SPECIFICATION?

    HOW DOES MIS-SPECIFICATION RESOLVE OVER TIME?

  • Damage ResponseS

    HOW DO EPITHELIA RESPOND TO DIFFERENT TYPES OF DAMAGE?

  • Lineage Dynamics

    HOW DO STEM CELL LINEAGE TRAJECTORIES EVOLVE THROUGHOUT DEVELOPMENT AND TUMORIGENESIS?

  • Mechanistic Conservation

    WHAT STEM CELL REGULATORY MECHANISMS ARE CONSERVED AMONG DISTINCT EPITHELIAL TISSUES?